Safety screening involves the carrying out of toxicity tests on a medicinal product so as to determine the safety profile of the product. In this study, the medicinal product under study was a herbal product C00112, claimed to be a hepatoprotective agent. There are a number of causes of liver disease such as injections (both viral and parasitic), the use of drugs such as Acetaminophen, Amoxicillin, Amiodarone, Chlorpromazine among others and excessive alcohol consumption. A hepatoprotective agent would therefore be of importance when it comes to the management of liver disease. However, since this product is a herbal formulation, issues of safety, effectiveness and quality are bound to arise hence the need for safety screening.